{"id":3432,"date":"2020-05-01T11:56:00","date_gmt":"2020-05-01T09:56:00","guid":{"rendered":"https:\/\/cedkqn.med.uni-giessen.de\/?p=3432"},"modified":"2022-06-15T10:38:57","modified_gmt":"2022-06-15T08:38:57","slug":"lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels","status":"publish","type":"post","link":"https:\/\/cedkqn.med.uni-giessen.de\/index.php\/2020\/05\/01\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\/","title":{"rendered":"Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels"},"content":{"rendered":"\n<p>Kandavel et al&nbsp;<sup>(1)<\/sup>&nbsp;retrospectively investigated the value of mean corpuscular volume to white blood cell (MCV\/WBC) ratio as estimates for 6-TG levels, and further as surrogate marker for thiopurine efficacy in pediatric inflammatory bowel disease (PIBD) patients treated with thiopurine in their center. Their analysis was based on 440 PIBD patients with complete blood cell count, 441 patients with ESR or CRP values, 111 patients with physician global assessment (PGA) evaluation, but only 53 patients with 6-TG levels available. No information on concomitant drugs, endoscopic findings or disease activity scores like the wPCDAI were given. The MCV\/WBC ratio was poorly related to ESR and CrP and not significantly associated with the 4 categories of PGA. The concluding AuROC analysis showed poor results for prediction of quiescent disease (defined by normal PGA and ESR or CrP) by either MCV\/WBC (n = 107) or 6-TG (n = 14!). In spite of these findings and major limitations of the study as pointed out in the Editorial by Bousvaros&nbsp;<sup>(2)<\/sup>, the authors conclude \u201cthat the MCV\/WBC ratio provides an accurate, easy, and low-cost alternative method for therapeutic monitoring of thiopurine medications.\u201d<\/p>\n\n\n\n<p>To test the reliability of MCV\/WBC as \u201ca poor man&#8217;s drug level\u201d for thiopurine efficacy, we analyzed data from the PIBD registry of the Society for Paediatric Gastroenterology of German-speaking countries;&nbsp;<a href=\"http:\/\/www.gpge.eu\/\">www.gpge.eu<\/a>). The registry includes data on more than 5000 children and adolescents with IBD with &gt;50,000 documented contacts reported by &gt;50 PIBD outpatient clinics from 2004 onwards.<\/p>\n\n\n\n<p>Weiterlesen: <a href=\"https:\/\/journals.lww.com\/jpgn\/Fulltext\/2020\/05000\/Lack_of_Correlation_of_Mean_Corpuscular_Volume_to.34.aspx\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/journals.lww.com\/jpgn\/Fulltext\/2020\/05000\/Lack_of_Correlation_of_Mean_Corpuscular_Volume_to.34.aspx<\/a>&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"http:\/\/cedkqn.med.uni-giessen.de\/wp-content\/uploads\/2022\/02\/Lack_of_Correlation_of_Mean_Corpuscular_Volume_to.34.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">DOWNLOAD<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Kandavel et al&nbsp;(1)&nbsp;retrospectively investigated the value of mean corpuscular volume to white blood cell (MCV\/WBC) ratio as estimates for 6-TG levels, and further as surrogate marker for thiopurine efficacy in pediatric inflammatory bowel disease (PIBD) patients treated with thiopurine in their center. Their analysis was based on 440 PIBD patients with complete blood cell count, &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/cedkqn.med.uni-giessen.de\/index.php\/2020\/05\/01\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\/\"> <span class=\"screen-reader-text\">Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels<\/span> Weiterlesen &raquo;<\/a><\/p>\n","protected":false},"author":13,"featured_media":3402,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"categories":[3],"tags":[13,17,12,15],"class_list":["post-3432","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-presse","tag-ced","tag-chronisch-entzuendliche-darmerkrankungen","tag-inflammatory-bowel-disease","tag-pediatric-patients"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels - CEDKQN<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels - CEDKQN\" \/>\n<meta property=\"og:description\" content=\"Kandavel et al&nbsp;(1)&nbsp;retrospectively investigated the value of mean corpuscular volume to white blood cell (MCV\/WBC) ratio as estimates for 6-TG levels, and further as surrogate marker for thiopurine efficacy in pediatric inflammatory bowel disease (PIBD) patients treated with thiopurine in their center. Their analysis was based on 440 PIBD patients with complete blood cell count, &hellip; Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels Weiterlesen &raquo;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cedkqn.med.uni-giessen.de\/index.php\/2020\/05\/01\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\/\" \/>\n<meta property=\"og:site_name\" content=\"CEDKQN\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-01T09:56:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-06-15T08:38:57+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/cedkqn.med.uni-giessen.de\/wp-content\/uploads\/2022\/02\/Thiopurine.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1232\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Laura Eckes\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Geschrieben von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Laura Eckes\" \/>\n\t<meta name=\"twitter:label2\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data2\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/index.php\\\/2020\\\/05\\\/01\\\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/index.php\\\/2020\\\/05\\\/01\\\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\\\/\"},\"author\":{\"name\":\"Laura Eckes\",\"@id\":\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/#\\\/schema\\\/person\\\/68731aaa8c70de3b8bfaadd6889e16be\"},\"headline\":\"Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels\",\"datePublished\":\"2020-05-01T09:56:00+00:00\",\"dateModified\":\"2022-06-15T08:38:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/index.php\\\/2020\\\/05\\\/01\\\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\\\/\"},\"wordCount\":277,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/index.php\\\/2020\\\/05\\\/01\\\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/Thiopurine.jpg\",\"keywords\":[\"ced\",\"chronisch entz\u00fcndliche Darmerkrankungen\",\"inflammatory bowel disease\",\"pediatric patients\"],\"articleSection\":[\"Presse\"],\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/index.php\\\/2020\\\/05\\\/01\\\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/index.php\\\/2020\\\/05\\\/01\\\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\\\/\",\"url\":\"https:\\\/\\\/cedkqn.med.uni-giessen.de\\\/index.php\\\/2020\\\/05\\\/01\\\/lack-of-correlation-of-mean-corpuscular-volume-to-white-blood-cell-ratio-to-thiopurine-levels\\\/\",\"name\":\"Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels - 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