Laura Eckes

Early Immunosuppression in Children and Adolescents with Crohn’s Disease

15. Juni 2022

DATA FROM THE CEDATA GPGE REGISTRY To date, failure of the first-line medical management of Crohn’s disease (CD) in children and adolescents has been followed by escalation treatment, with administration of immunomodulators, e.g., azathioprine, or biologics, such as infliximab (1). The most recent revision of the international guideline proposes stratification of the therapy, with selection …

Early Immunosuppression in Children and Adolescents with Crohn’s Disease Weiterlesen »

Incidence trends of pediatric onset inflammatory bowel disease in the years 2000-2009 in Saxony, Germany-first results of the Saxon Pediatric IBD Registry

15. Juni 2022

Abstract Aims: In developed countries, the incidence of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) is increasing. Therefore, we aimed to investigate the incidence rates and trends over time in the population of children and adolescents in one of the federal states of Germany, in Saxony. Methods: Over the 10-year period …

Incidence trends of pediatric onset inflammatory bowel disease in the years 2000-2009 in Saxony, Germany-first results of the Saxon Pediatric IBD Registry Weiterlesen »

Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels

15. Juni 2022

Kandavel et al (1) retrospectively investigated the value of mean corpuscular volume to white blood cell (MCV/WBC) ratio as estimates for 6-TG levels, and further as surrogate marker for thiopurine efficacy in pediatric inflammatory bowel disease (PIBD) patients treated with thiopurine in their center. Their analysis was based on 440 PIBD patients with complete blood cell count, …

Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels Weiterlesen »

Incidence and Risk Factors for Perianal Disease in Pediatric Crohn Disease Patients Followed in CEDATA-GPGE Registry

19. September 2023

Annecarin Brückner, Katharina J Werkstetter, Jan de Laffolie, Claudia Wendt, Christine Prell, Tanja Weidenhausen, Klaus P Zimmer, Sibylle Koletzko; CEDATA-GPGE study group PMID: 28604511 DOI: 10.1097/MPG.0000000000001649 Abstract Objectives: Perianal disease (PD) with fistula and/or abscess formation is a severe complication in Crohn disease (CD). We examined prevalence, incidence, and risk factors for PD development in a pediatric CD …

Incidence and Risk Factors for Perianal Disease in Pediatric Crohn Disease Patients Followed in CEDATA-GPGE Registry Weiterlesen »

Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE

15. Juni 2022

Abstract Aim: To determine the prevalence of anemia and its association with disease severity in children and adolescents with IBD. Methods: CEDATA-GPGE is a registry for pediatric patients with IBD in Germany and Austria from 90 specialized centers. As markers of disease severity, analysis included patient self-assessment on a Likert scale (1-5; 1 = very good) and …

Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE Weiterlesen »