Crohn’s Disease Exclusion Diet – an alternative to exlusive enteral nutritional therapy in children and adolescents with Crohn’s disease?

15. Juni 2022

Statement of the GPGE working groups CEDATA and Nutrition/Nutrition Medicine AbstactEpidemiologische und klinische Beobachtungen sowie Tiermodelle weisen auf die Ernährung als Risikofaktor für die Entwicklung einer chronisch entzündlichen Darmerkrankung (CED) hin. Die exklusive enterale Ernährungstherapie (EET) ist das Musterbeispiel einer effektiven Entzündungskontrolle durch eine rein diätetische Intervention. Ausgehend davon haben Patienten, Familien und betreuende Fachkräfte …

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Running Behind „POPO“ – Impact of Predictors of Poor Outcome for Treatment Stratification in Pediatric Crohn’s Disease

15. Juni 2022

ABSTRACT – Background and Aims: Intensifying therapy for Paediatric Crohn’s Disease (CD) by early use of immunomodulators and biologics has been proposed for cases in which predictors of poor outcome (POPO) were present. We investigated therapy stratifying potential comparing POPO-positive and -negative CD patients from CEDATA-GPGE®, a German-Austrian Registry for Paediatric Inflammatory Bowel disease.  Methods: CD patients …

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Early Immunosuppression in Children and Adolescents with Crohn’s Disease

15. Juni 2022

DATA FROM THE CEDATA GPGE REGISTRY To date, failure of the first-line medical management of Crohn’s disease (CD) in children and adolescents has been followed by escalation treatment, with administration of immunomodulators, e.g., azathioprine, or biologics, such as infliximab (1). The most recent revision of the international guideline proposes stratification of the therapy, with selection …

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Machine Learning Classification of Inflammatory Bowel Disease in Children Based on a Large Real-World Pediatric Cohort CEDATA-GPGE Registry

15. Juni 2022

Abstract Introduction: The rising incidence of pediatric inflammatory bowel diseases (PIBD) facilitates the need for new methods of improving diagnosis latency, quality of care and documentation. Machine learning models have shown to be applicable to classifying PIBD when using histological data or extensive serology. This study aims to evaluate the performance of algorithms based on promptly …

Machine Learning Classification of Inflammatory Bowel Disease in Children Based on a Large Real-World Pediatric Cohort CEDATA-GPGE Registry Weiterlesen »

Incidence trends of pediatric onset inflammatory bowel disease in the years 2000-2009 in Saxony, Germany-first results of the Saxon Pediatric IBD Registry

15. Juni 2022

Abstract Aims: In developed countries, the incidence of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) is increasing. Therefore, we aimed to investigate the incidence rates and trends over time in the population of children and adolescents in one of the federal states of Germany, in Saxony. Methods: Over the 10-year period …

Incidence trends of pediatric onset inflammatory bowel disease in the years 2000-2009 in Saxony, Germany-first results of the Saxon Pediatric IBD Registry Weiterlesen »

CED-KQN-Data quality assurance in digital clinical registries

15. Juni 2022

Clinical registries have been proven as a vital tool to further research concerning rare diseases like pediatric onset inflammatory bowel disease (PIBD) as they aggregate a sufficient amount of data for a better understanding of disease phenotypes and timeline and the support of clinical trials.

Analyse leitliniengerechter Diagnostik und Zeit bis zur Diagnose chronisch entzündlicher Darmerkrankungen bei pädiatrischen Patienten

15. Juni 2022

Ergebnisse aus dem deutschsprachigen Patientenregister CEDATA-GPGE Zu den chronisch entzündlichen Darmerkrankungen (CED) zählen Morbus Crohn, Colitis Ulcerosa und die indeterminierte Colitis. In der praktischen Versorgung von Kindern und Jugendlichen mit CED bilden die Leitlinien der Europäischen Gesellschaft für Gastroenterologie, Hepatologie und Ernährung (ESPGHAN) den höchsten Standard evidenzbasierter Diagnostik und Therapie.

Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels

15. Juni 2022

Kandavel et al (1) retrospectively investigated the value of mean corpuscular volume to white blood cell (MCV/WBC) ratio as estimates for 6-TG levels, and further as surrogate marker for thiopurine efficacy in pediatric inflammatory bowel disease (PIBD) patients treated with thiopurine in their center. Their analysis was based on 440 PIBD patients with complete blood cell count, …

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CED-KQN-Verbesserung der Versorgung für Kinder und Jugendliche mit chronisch entzündlichen Darmerkrankungen CED KQN

15. Juni 2022

medizinische Bedeutung und Versorgung Chronisch entzündliche Darmerkrankungen bei Kindern und Jugendlichen spielen eine zunehmende Rolle mit steigender Inzidenz sowie schwieriger Versorgungssituation. Es wird jährlich von rund 1200-1800 Neuerkrankungen in Deutschland ausgegangen. Das Register CEDATA-GPGE versucht die Versorgung zu verbessern und mittels moderner Techniken aus den Daten zu lernen.